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  • Title: Synthesis and antibacterial activity of 7-(substituted)aminomethyl quinolones.
    Author: Zhang Z, Zhou W, Yu A.
    Journal: Bioorg Med Chem Lett; 2004 Jan 19; 14(2):393-5. PubMed ID: 14698166.
    Abstract:
    A series of 7-(substituted)aminomethyl quinolones was synthesized and evaluated for antibacterial activity. Derivatives with (monoalkyl)aminomethyl substituent at C-7 displayed high in vitro activities comparable to Lomefloxacin against gram-negative organisms, whereas those bearing a [(substituted)phenyl]aminomethyl side chain at C-7 demonstrated good activities against gram-positive organisms as potent as Lomefloxacin and Vancomycin.
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