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  • Title: [The evaluation of thyroid nodules: is routine use of frozen-section examination necessary following preoperative fine-needle aspiration biopsy? ].
    Author: Saydam L, Kalcioğlu MT, Kizilay A, Bozkurt MK.
    Journal: Kulak Burun Bogaz Ihtis Derg; 2003 Sep; 11(3):80-4. PubMed ID: 14699248.
    Abstract:
    OBJECTIVES: We evaluated the role of fine-needle aspiration biopsy as a single parameter in determining the extent of thyroidectomy and the necessity of routine use of frozen-section examination in patients with nodular thyroid disease. PATIENTS AND METHODS: We reviewed 67 patients (40 females, 27 males; mean age 44 years; range 17 to 78 years) who underwent thyroidectomy for nodular thyroid disease. Preoperative fine-needle aspiration biopsy and intraoperative frozen-section examination were performed in 46 patients and 40 patients, respectively. The results were compared with histopathologic diagnoses. RESULTS: Histopathologically, 25 patients (37.3%) had malignant and 42 patients (62.7%) had benign disease. The sensitivity, specificity, and diagnostic accuracy were 50%, 95%, and 77% for fine-needle aspiration biopsy, and 100%, 87%, and 91% for frozen-section examination, respectively. CONCLUSION: In view of lower sensitivity and accuracy rates for fine-needle aspiration biopsy, the routine use of frozen-section examination seems to be necessary especially in cases with highly suggestive clinical findings of malignancy.
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