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  • Title: Management of acute cancer treatment-induced diarrhea.
    Author: Stern J, Ippoliti C.
    Journal: Semin Oncol Nurs; 2003 Nov; 19(4 Suppl 3):11-6. PubMed ID: 14702928.
    Abstract:
    OBJECTIVES: To describe the dietary and pharmacologic management of acute CTID. DATA SOURCES: Primary and secondary literature, and clinical experience. CONCLUSION: When dietary strategies do not work, or when patients present with grade 3/4 diarrhea, pharmacologic intervention is required. First-line therapy should be initiated quickly with loperamide or diphenoxylate/atropine in recommended doses. Somatostatin analogues are effective as second-line therapy or as first-line therapy for patients with grade 3/4 diarrhea. IMPLICATIONS FOR NURSING PRACTICE: Oncology nurses should strive to match treatment with the severity of symptoms of CTID. Whatever therapy is chosen, the goal must be to quickly control this debilitating and potentially life-threatening side effect so that primary chemotherapy and/or radiation therapy may be resumed and completed.
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