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  • Title: [Infection of human papillomavirus in oral benign epithelial proliferation in children].
    Author: Liu LK, He ZX, Li YN, Yi XZ.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2003 Nov; 38(6):426-8. PubMed ID: 14703474.
    Abstract:
    OBJECTIVE: To investigate the presence of HPV infection of oral mucosa proliferative lesions in children and determine the associations of HPV types with oral mucosa lesions in children. METHODS: Immunohistochemical method and in situ hybridization techniques were applied to detect human papillomavirus (HPV) infection in biopsies taken from clinical lesions in oral mucosa of 30 children. RESULTS: The most frequent lesions detected were SCP (66.7%), followed by CA and FEH. The HPV viral antigen was present in 73.3% (22/30) of the oral benign epithelial proliferative lesions in children. A high frequency HPV was found in CA (6/6) and SCP (15/20) by means of IHC. In the ISH positive case, high risk HPV 16/18 was observed in 77.3% (17/22). CONCLUSION: This study demonstrates a high prevalence of HPV infection in children's oral mucosa proliferative lesions, and high-risk HPV16/18 are predominant in children's oral mucosa proliferative lesions.
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