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  • Title: Nicotine diminishes anticonvulsant activity of antiepileptic drugs in mice.
    Author: Czuczwar M, Kiś J, Czuczwar P, Wielosz M, Turski W.
    Journal: Pol J Pharmacol; 2003; 55(5):799-802. PubMed ID: 14704477.
    Abstract:
    Nicotine administered acutely at subconvulsive dose of 4 mg/kg, significantly decreased the protective activity of valproate, carbamazepine, diphenylhydantoin, phenobarbital, topiramate and lamotrigine against maximal electroshock-induced tonic convulsions in mice. The obtained data may suggest that interaction between nicotine and antiepileptic drugs should be carefully considered as a cause of the therapeutic failure in epileptic patients.
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