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  • Title: Antidepressant effect of carbamazepine--the role of dopaminergic and noradrenergic agents.
    Author: Słuzewska A, Chodera A.
    Journal: Pol J Pharmacol Pharm; 1992; 44(3):209-15. PubMed ID: 1470559.
    Abstract:
    Fourteen days of treatment with 20 mg/kg/day carbamazepine (CBZ) reduced the immobility time in the behavioral "despair" test in rats. Two blockers of dopaminergic receptors: haloperidol (0.5 mg/kg) and sulpiride (100 mg/kg) antagonized the reduction of immobility caused by CBZ. The anti-immobility effect of CBZ was also counteracted by clonidine (0.1 mg/kg) an agonist of presynaptic alpha 2 adrenoreceptors and propranolol (5 mg/kg) beta-adrenolytic drug.
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