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  • Title: Competitive, reversible, physiological? Inhibition of mitochondrial cytochrome oxidase by nitric oxide.
    Author: Cooper CE.
    Journal: IUBMB Life; 2003; 55(10-11):591-7. PubMed ID: 14711004.
    Abstract:
    In the mid 1990s a number of research groups recognized that mitochondrial oxygen consumption could be reversibly inhibited by nitric oxide at the level of the enzyme cytochrome c oxidase. The inhibition was apparently competitive with respect to the oxygen concentration. This review critically assesses the present state of knowledge as regards the hypothesis that nitric oxide is a competitive, reversible, physiological inhibitor of cytochrome oxidase.
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