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  • Title: [Serum anti-titin antibody in patients with myasthenia gravis].
    Author: Li YF, Zhang JB, Cui LY.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2003 Dec; 25(6):725-7. PubMed ID: 14714322.
    Abstract:
    OBJECTIVE: To study the clinical significance of serum anti-titin antibody level in the diagnosis of myasthenia gravis (MG) with thymoma. METHOD: The serum anti-titin antibody was analysed by ELISA method in 40 cases of health control group, 90 cases of MG, 17 cases of MG with thymoma and 7 cases of no-MG thymoma. The positive rate was compared among these groups. RESULTS: The positive rate of anti-titin antibody was significantly higher in MG with thymoma patients than MG patients (94% and 3%, P < 0.01). According to the Osserman's classification, anti-titin antibody was present mostly in patients (43%) in IV stage, and also present in 2 cases of 7 who with no-MG thymoma. CONCLUSION: Serum anti-titin antibody test is helpful in the diagnosis of MG with thymoma.
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