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  • Title: Study of chronic schizophrenics using 31P magnetic resonance chemical shift imaging.
    Author: Fujimoto T, Nakano T, Takano T, Hokazono Y, Asakura T, Tsuji T.
    Journal: Acta Psychiatr Scand; 1992 Dec; 86(6):455-62. PubMed ID: 1471539.
    Abstract:
    Phosphorus-31 chemical shift imaging showed regional abnormalities of in vivo 31P NMR spectra in the brains of chronic schizophrenic patients. In the left temporal region, the level of % phosphodiesters (PDE) was increased and the level of % gamma alpha beta-ATP (obtained by summation of gamma-ATP, alpha-ATP, and beta-ATP) was decreased. In the basal ganglia, the levels of % PDE were decreased and the level of % phosphomonoesters was increased. The levels of % gamma alpha beta-ATP were increased in the right basal ganglia. The level of % phosphocreatine was decreased in the frontoparietal region. These findings may represent different patterns of dysfunction of membrane phospholipid bilayers and high-energy phosphate metabolism in the specific cerebral regions.
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