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  • Title: Adrenal function of children with bronchial asthma treated with beclomethasone dipropionate.
    Author: Katsunuma T, Akasawa A, Iikura Y.
    Journal: Ann Allergy; 1992 Dec; 69(6):529-32. PubMed ID: 1471788.
    Abstract:
    The function of the hypothalamic-pituitary-adrenal (HPA) axis was investigated in nine asthmatic children treated by inhalation of beclomethasone dipropionate (300 micrograms/day) for 12 weeks. The trial was designed as a prospective study. The 24-hour urinary free cortisol, serum cortisol, response to ACTH, and nocturnal serum cortisol followed by 20-minute sampling were measured before and after the study period. No significant changes were found, suggesting that inhaled beclomethasone, in a daily dose of 300 micrograms, does not cause suppression of the HPA axis.
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