These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Decreased agglutinability of human erythrocytes by attachment of methoxy polyethylene glycol and the effect on erythrocyte oxygen-carrying ability.
    Author: Ong K, Dimacali K, Quintos R.
    Journal: Clin Hemorheol Microcirc; 2003; 29(3-4):401-7. PubMed ID: 14724367.
    Abstract:
    In the interest of creating readily transfusable blood, we have developed a method of covalently bonding methoxy polyethylene gylcol (mPEG) to the erythrocyte membrane to mask antigens which would otherwise cause immunorejection in unmatched blood transfusions. Previous studies have reported the ability of mPEG to mask erythrocyte antigens without significantly affecting viability, morphology, deformability, and other membrane functions. Our spectrophotometric analysis of modified erythrocytes has shown that as well as its other properties, mPEG-coated red blood cells can still take up oxygen, while remaining antigenically silent.
    [Abstract] [Full Text] [Related] [New Search]