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  • Title: [Aldosterone receptor antagonists in heart failure. Rightly brought back from retirement].
    Author: Kolloch R, Offers E.
    Journal: MMW Fortschr Med; 2003 Nov 20; 145(47):42-4, 47. PubMed ID: 14725033.
    Abstract:
    There is growing evidence that aldosterone plays an important role in the development of endorgan-damage e.g. vascular and cardiac fibrosis, remodeling and endothelial dysfunction. Aldosterone-antagonism has become a novel therapeutic principle beyond its sodium retention properties in the treatment of cardiovascular diseases. In patients with severe left ventricular dysfunction spironolactone could reduce death and hospitalisation. A new selective aldosterone antagonist, eplerenone, was effective in patients with left ventricular dysfunction after myocardial infarction added to optimal medical therapy.
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