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  • Title: [Toll type receptors: molecular bases of the relationship between innate and adaptation responses of the immune system].
    Author: Moreno C, Sánchez-Ibarrola A.
    Journal: Rev Med Univ Navarra; 2003; 47(3):29-33. PubMed ID: 14727572.
    Abstract:
    Microbes have on their surface molecular patterns that are common among a broad range of pathogens. These patterns are recognized by a wide variety of cellular receptors, the most important of which are a family of transmembrane proteins termed "Toll-like receptors" (TLR). TLRs are pattern-recognition receptors that have key roles in detecting pathogens and initiating inflammatory responses. The receptor of Gram negative bacterial LPS, TLR4, is the best characterized member of the TLR family. So far, ten mammalian toll-like receptors (TLR1-TLR10) have been identified. Recent studies revealed that the TLR signaling pathway is a critical mediator of sepsis. An understanding of TLRs and their signaling pathway will reveal a therapeutic target in sepsis and other immune mediated diseases.
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