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  • Title: In vitro antibacterial activity of the peptide PsVP-10 against antimicrobial-resistant Enterococcus faecalis isolated from clinical samples.
    Author: Padilla C, Lobos O, Brevis P, Abaca P, Hubert E.
    Journal: J Antimicrob Chemother; 2004 Feb; 53(2):390-2. PubMed ID: 14729763.
    Abstract:
    OBJECTIVE: To analyse the antimicrobial activity of the peptide PsVP-10 against 67 resistant Enterococcus faecalis strains isolated from clinical samples. METHODS: The qualitative disc diffusion method and MIC determinations were used. RESULTS: The presence of several multidrug-resistant phenotypes of E. faecalis was demonstrated, in which there were high MICs to chloramphenicol, tetracycline, vancomycin, cefaloridine, ampicillin and gentamicin. In comparison, the peptide PsVP-10 showed lower MICs against all the multidrug-resistant and susceptible E. faecalis. CONCLUSIONS: There is an urgent need for the development of novel antimicrobial agents against the highly resistant E. faecalis. The present study shows that the peptide PsVP-10 might make a contribution to the solution of this serious problem.
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