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  • Title: Fibrin ring granulomas in hepatitis A.
    Author: Ruel M, Sevestre H, Henry-Biabaud E, Courouce AM, Capron JP, Erlinger S.
    Journal: Dig Dis Sci; 1992 Dec; 37(12):1915-7. PubMed ID: 1473440.
    Abstract:
    Fibrin ring granuloma is characterized by a fibrinous ring surrounding a central fat vacuole. It has been found in the liver and bone marrow of patients with Q fever, and occasionally with visceral leishmaniasis, cytomegalovirus, Epstein-Barr virus, Staphylococcus epidermidis infections, Hodgkin's lymphoma, and hypersensitivity to allopurinol. We describe a case of serologically confirmed viral hepatitis A with this lesion in the liver biopsy. A false positive anti-hepatitis A virus IgM result has been excluded. This is, to our knowledge, the second reported case of type A hepatitis with hepatic fibrin ring granulomas. It confirms that hepatitis A should be included in the differential diagnosis of this lesion.
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