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  • Title: Micromide and guamamide: cytotoxic alkaloids from a species of the marine cyanobacterium Symploca.
    Author: Williams PG, Yoshida WY, Moore RE, Paul VJ.
    Journal: J Nat Prod; 2004 Jan; 67(1):49-53. PubMed ID: 14738385.
    Abstract:
    Two new cytotoxins have been isolated from a species of marine cyanobacterium belonging to the genus Symploca that was collected in Guam. These new compounds, micromide (1) and guamamide (2), were accompanied by the known lipopeptides apramides A (3), B (4), and G (5). The planar structures of both alkaloids were elucidated by standard 2D NMR techniques, and the configurations of the amino acid-derived units in 1 were determined by chiral HPLC. The stereochemistry of the beta-methoxyhexanoic acid in 1 was determined by derivatization with methyl d-mandelate, after acid hydrolysis, and comparison with synthetic standards.
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