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  • Title: Comparison of vascular opacification after bolus injection of iodixanol-320 iohexol-350.
    Author: Gould R, Brasch RC, Sievers R, Baxter A, Aicher K.
    Journal: Invest Radiol; 1992 Dec; 27(12):1031-4. PubMed ID: 1473920.
    Abstract:
    RATIONALE AND OBJECTIVES: The vascular opacification characteristics of a new nonionic, dimeric contrast agent, iodixanol, have been compared with a nonionic, monomeric agent, iohexol, using ultrafast computed tomography (UFCT). METHODS: In 10 experiments with mongrel dogs, the contrast agents were alternately injected into the animal's left atrium, and UFCT images were obtained at four cross-sectional levels through the carotid arteries. Time-density curves were then obtained for each carotid artery and each agent. The peak height and area under the curves were compared for each agent. RESULTS: Iohexol provided significantly (P < or = .05) greater opacification, determined by paired Student's t tests. CONCLUSION: This result was predicted from the greater iodine concentration of iohexol (350 mg/mL) compared with iodixanol (320 mg/mL); the difference was greater than expected based on iodine content alone.
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