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  • Title: Synthesis and biological activity of O56-substituted carboxyesters and carboxamides of teicoplanin aglycone.
    Author: Seneci P, Trani A, Ferrari P, Scotti R, Ciabatti R.
    Journal: J Antibiot (Tokyo); 1992 Oct; 45(10):1633-44. PubMed ID: 1473991.
    Abstract:
    A series of O56-substituted carboxyester or carboxyamide derivatives of deglucoteicoplanin (TD) was prepared by condensation of the 56-hydroxyl function with various alkylating agents of general formula RBr, where R represents functional groups with different physico-chemical properties. The modifications at position 56 influenced the antimicrobial activity of the new derivatives; activity depended on the structure of various R groups, their ionic properties, and their steric hindrance. The activity of the new compounds did not show any significant improvement when compared with TD. The physico-chemical and antibacterial properties of the synthesized compounds are reported.
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