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  • Title: Protection of mice with recombinant influenza virus neuraminidase.
    Author: Kilbourne ED, Pokorny BA, Johansson B, Brett I, Milev Y, Matthews JT.
    Journal: J Infect Dis; 2004 Feb 01; 189(3):459-61. PubMed ID: 14745703.
    Abstract:
    Contemporary influenza vaccines are standardized with respect to their content of hemagglutinin, the major virus antigen. Although the immunizing effect of viral neuraminidase--the less abundant of the 2 major surface glycoproteins--has been well documented in experimental animals, the importance of the purified recombinant protein has not yet been adequately assessed in animals or humans. We demonstrate that different lots of a baculovirus-derived recombinant N2 protein, in the absence of other influenza virus proteins, can induce neuraminidase-specific antibodies, reduce the replication of both homologous and heterovariant virus in mice, and suppress disease, as it is manifested by total body weight loss.
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