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  • Title: Fetal bilateral renal agenesis, phocomelia, and single umbilical artery associated with cocaine abuse in early pregnancy.
    Author: Kashiwagi M, Chaoui R, Stallmach T, Hürlimann S, Lauper U, Hebisch G.
    Journal: Birth Defects Res A Clin Mol Teratol; 2003 Nov; 67(11):951-2. PubMed ID: 14745934.
    Abstract:
    BACKGROUND: Maternal cocaine abuse in pregnancy is associated with complications such as intrauterine growth retardation, abruptio placentae, and preterm delivery. CASE: We report what is, to our knowledge, the first published observation of fetal bilateral renal agenesis associated with a vascular disruption syndrome comprising upper limb reduction defect and a single umbilical artery following maternal cocaine abuse in early pregnancy. CONCLUSIONS: This constellation in a fetus aborted at 18 weeks extends the spectrum of complications possibly associated with cocaine abuse in pregnancy.
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