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  • Title: Glycosidic bond cleavage of thymidine by low-energy electrons.
    Author: Zheng Y, Cloutier P, Hunting DJ, Wagner JR, Sanche L.
    Journal: J Am Chem Soc; 2004 Feb 04; 126(4):1002-3. PubMed ID: 14746451.
    Abstract:
    Thymidine was exposed to low-energy electrons (LEE) as a thin solid film under a high vacuum. Nonvolatile radiation products, remaining on the irradiated surface, were analyzed by HPLC/UV and GC/MS. Here, we show that exposure of thymidine to 3-100 eV electrons gives thymine as a major product with a yield of 3.2 x 10-2 per electron (about one-third of the total decomposition of thymidine). The formation of thymine indicates that LEE induces cleavage of the glycosidic bond separating the base and sugar moieties, suggesting a nonionizing resonant process involving dissociative attachment (<15 eV). In contrast, this reaction is not very efficient by DNA base ionization and does not occur by the reaction of solvated electrons with DNA. These studies introduce a new mechanism of DNA damage involving the interaction of LEE.
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