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  • Title: Optimal designs for Michaelis-Menten kinetic studies.
    Author: Matthews JN, Allcock GC.
    Journal: Stat Med; 2004 Feb 15; 23(3):477-91. PubMed ID: 14748040.
    Abstract:
    Many reactions in enzymology are governed by the Michaelis-Menten equation. Characterising these reactions requires the estimation of the parameters K(M) and V(max) which determine the Michaelis-Menten equation and this is done by observing rates of reactions at a set of substrate concentrations. The choice of substrate concentrations is investigated by determining Bayesian D-optimal designs for a model in which residuals have a normal distribution with constant variance. Designs which focus on alternative quantities, such as K(M) or the ratio V(max)/K(M) are also considered. The effect on the optimal designs of alternative error distributions is also considered.
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