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  • Title: First total synthesis of mycothiol and mycothiol disulfide.
    Author: Lee S, Rosazza JP.
    Journal: Org Lett; 2004 Feb 05; 6(3):365-8. PubMed ID: 14748594.
    Abstract:
    [reaction: see text] The first total synthesis of mycothiol and mycothiol disulfide was achieved by linking D-2,3,4,5,6-penta-O-acetyl-myo-inositol, O-(3,4,6-tri-O-acetyl)-2-azido-2-deoxy-alpha,beta-D-glucopyranosyl) trichloroacetimidate, and N,S-diacetyl-L-cysteine and deprotecting peracetylated mycothiol. The first full spectral characterization is reported for underivatized mycothiol. The structure of mycothiol was confirmed by spectral analysis of the known bimane derivative.
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