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  • Title: Prolactin regulation of pro-opiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus.
    Author: Tong Y, Pelletier G.
    Journal: Neuroendocrinology; 1992 Oct; 56(4):561-5. PubMed ID: 1475014.
    Abstract:
    It is well known that the opiate peptides, especially the pro-opiomelanocortin (POMC)-related peptide beta-endorphin, stimulate the release of prolactin (PRL) in the rat. In order to evaluate the involvement of PRL on the activity of POMC neurons in the arcuate nucleus, we have studied the effects of the injection of PRL into the third ventricle of intact and hypophysectomized rats as well as the effects of hyperprolactinemia induced by pituitary implants under the kidney capsule on POMC gene expression. The amounts of POMC mRNA in the arcuate nucleus were measured by in situ hybridization using a [35S]-labelled cDNA probe encoding for POMC. Hypophysectomy performed 2 weeks previously decreased by 24% the number of silver grains/unit of surface of labelled neurons. Intracerebroventricular injection of 3 micrograms of PRL 4 h before sacrifice induced a significant decrease in the hybridization signal of 32 and 20% in the intact and hypophysectomized rat, respectively. Hyperprolactinemia achieved by pituitary implants also led to a significant decrease in POMC mRNA levels. The present data show that hypophysectomy depresses hypothalamic POMC mRNA levels and that this effect is not related to the suppression of PRL secretion since this hormone exerts an inhibitory action on POMC gene expression. They suggest that the regulation of PRL secretion by short loop feedback mechanism might be well mediated by beta-endorphin which has already been shown to inhibit dopaminergic neuron activity in the arcuate nucleus.
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