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  • Title: Second-trimester maternal serum immunoreactive inhibin as a marker for fetal Down's syndrome.
    Author: Van Lith JM, Pratt JJ, Beekhuis JR, Mantingh A.
    Journal: Prenat Diagn; 1992 Oct; 12(10):801-6. PubMed ID: 1475248.
    Abstract:
    We measured immunoreactive inhibin in the maternal serum of 80 pregnancies with a chromosomally normal fetus and ten Down's syndrome pregnancies in the second trimester. The inhibin level in all Down's syndrome pregnancies was above the normal median; the multiple of the normal median (MoM) was 1.9. We found a statistically significant difference between the levels of inhibin in unaffected and affected pregnancies (Kolmogorov-Smirnov test: p < 0.002). Using an arbitrarily chosen cut-off of 2.4 MoM, 40 per cent of Down's syndrome and 5 per cent of the normal pregnancies were found. We conclude that immunoreactive inhibin may be useful as a marker for fetal Down's syndrome.
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