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  • Title: Neuroprotective effect from ischemia and direct free radical scavenging activity of Choto-san (kampo medicine).
    Author: Dohi K, Satoh K, Ikeda Y, Ohtaki H, Shioda S, Aruga T.
    Journal: Acta Neurochir Suppl; 2003; 86():123-7. PubMed ID: 14753419.
    Abstract:
    Choto-san is a kampo medicine that is widely used in patients with cerebral infarction, but the details of its mechanism of action remain unclear. We examined the neuroprotective effects of Choto-san using an experimental cerebral ischemia model (i.e., a rat cardiac arrest model). We also investigated the ability of Choto-san to eliminate or inhibit the activity of free radicals. It was found that Choto-san significantly prevents delayed neuronal cell death after ischemic reperfusion. Electron spin resonance demonstrated that the formation of hydroxyl- and superoxide-DMPO spin adducts were inhibited by Choto-san. The results of this study indicated that Choto-san prevents delayed neuronal cell death in the hippocampal CA1 region after ischemia. Direct free radical scavenging activity is among the pharmacological effects of Choto-san.
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