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  • Title: Pharmacokinetic study and trial for preparation of enteric-coated capsule containing insulinomimetic vanadyl compounds: implications for clinical use.
    Author: Sakurai H, Fugono J, Yasui H.
    Journal: Mini Rev Med Chem; 2004 Jan; 4(1):41-8. PubMed ID: 14754442.
    Abstract:
    To treat patients suffering from diabetes mellitus, we developed several types of orally active vanadyl complexes to replace painful insulin injections, and prepared them in the form of enteric-coated capsules containing vanadium compounds. Pharmacokinetic analysis demonstrated that these capsules enhance the bioavailability of pharmacologically active vanadyl species.
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