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  • Title: Par-4 inducible apoptosis in prostate cancer cells.
    Author: Gurumurthy S, Rangnekar VM.
    Journal: J Cell Biochem; 2004 Feb 15; 91(3):504-12. PubMed ID: 14755681.
    Abstract:
    Prostate cancer is associated with the inability of prostatic epithelial cells to undergo apoptosis rather than with increased cell proliferation. Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic molecule that is capable of selectively inducing apoptosis in cancer cells when over-expressed, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. This review discusses the salient functions of Par-4 that can be harnessed to prostate cancer therapy.
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