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  • Title: Malaria and pregnancy in Cameroonian women. Naturally acquired antibody responses to asexual blood-stage antigens and the circumsporozoite protein of Plasmodium falciparum.
    Author: Mvondo JL, James MA, Sulzer AJ, Campbell CC.
    Journal: Trans R Soc Trop Med Hyg; 1992; 86(5):486-90. PubMed ID: 1475812.
    Abstract:
    Antibody responses to Plasmodium falciparum antigens in women during pregnancy were investigated in Mfou, a rural community in Cameroon. The study consisted of cross-sectional analyses involving 225 pregnant women and 75 non-pregnant controls. Blood samples were collected from each woman to determine serological reactivity to intraerythrocytic malarial antigens, ring-infected erythrocyte surface antigen (RESA) and circumsporozoite (CS) repeat peptide (NANP)5 by the indirect fluorescent antibody assay, modified immunofluorescent antibody assay, and enzyme-linked immunosorbent assay, respectively. Reactivity to intraerythrocytic asexual blood-stage antigens and to the CS repeat region was similar in both pregnant and non-pregnant women, and no correlation with parasitaemia was found. In contrast, anti-RESA antibody levels were significantly lower in pregnant than in non-pregnant women (P = 0.02) and in primigravidae than in multigravidae (P = 0.002), and were inversely correlated with parasitaemia (r = -0.36; P < 0.01). These data suggest that the increased susceptibility to malarial infection in pregnant women may be explained in part by their lower reactivity to RESA.
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