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  • Title: Metallothionein induction in aquatic oligochaete tubifex tubifex exposed to herbicide isoproturon.
    Author: Mosleh YY, Paris-Palacios S, Arnoult F, Couderchet M, Biagianti-Risbourg S, Vernet G.
    Journal: Environ Toxicol; 2004 Feb; 19(1):88-93. PubMed ID: 14758596.
    Abstract:
    Metallothioneins (MTs) are low-molecular-weight proteins mainly involved in metal ion detoxification. Recently it has been demonstrated that MTs participate in several cellular functions such as regulation of growth and antioxidative defenses. Moreover, pesticides can induce their synthesis. The aim of the current work was to determine the effects of isoproturon, either pure or formulated as Matin (suspension containing an isoproturon concentration of 500 g. L(-1)), on the metallothionein and total protein contents of the aquatic worm Tubifex tubifex. MT levels in exposed worms increased significantly after 7 and 15 days of exposure to a concentration of the herbicide of 50 mg. L(-1). Isoproturon reduced the metal (Cu, Zn, and Cd) content of metallothioneins, and it also increased the total protein content of the worms. These results suggest that MT induction may not be considered a specific biomarker of metal exposure but that it can be used as a nonspecific biomarker of the effect of isoproturon effect in aquatic worms.
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