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  • Title: [A study on biomarkers of styrene].
    Author: Shao H, Wang XY, Cheng H, Shi YK, Zhang MP.
    Journal: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi; 2003 Apr; 21(2):93-5. PubMed ID: 14761518.
    Abstract:
    OBJECTIVE: To study the biomarkers of styrene and to provide theoretical basis for bio-monitoring of styrene. METHODS: Urinary mandalic acid (MA), phenylglyoxalic acid (PGA) and mercapturic acid (MUA) of styrene were examined by high performance liquid chromatography (HPLC). RESULTS: The correlation regression equations between exposure dose and MA, PGA and MUA level in morning urinary samples were: ŷ = 2.58x + 70.82; ŷ = 1.66x + 37.42; ŷ = 0.05x + 0.55 respectively. The correlation regression equations between exposure dose and MA, PGA and MUA level in post-shift urinary samples were: ŷ = 1.85x + 89.02; ŷ = 1.33x + 4.32; ŷ = 0.04x + 0.68 respectively. All showed close dose-response relationship. CONCLUSIONS: The level of MA, PGA and MUA in morning or post-shift urinary samples may be used as bio-monitoring indexes of styrene.
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