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  • Title: Pharmacokinetics and urinary excretion of sulfadiazine in buffalo calves.
    Author: Jain SK, Uppal RP, Garg BD.
    Journal: Ann Rech Vet; 1992; 23(4):389-93. PubMed ID: 1476408.
    Abstract:
    Pharmacokinetics and urinary excretion of sulfadiazine were determined in buffalo calves following single oral administration (150 mg/kg). Kinetic evaluation of plasma levels was performed using a 2-compartment model. The absorption half-life and elimination half-life were 3.41 +/- 0.63 and 13.75 +/- 1.94 h, respectively. Based on this study, an optimal dosage regimen of sulfadiazine in buffalo calves would be 165 mg/kg, followed by 75 mg/kg at 12-h intervals. Sulfadiazine was mainly excreted in the urine as free amine, while the percentage of acetylated sulfadiazine was comparatively low.
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