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  • Title: Thrombocytosis in an infant with high thrombopoietin concentrations.
    Author: Hankins J, Naidu P, Rieman M, Wang W, Kaushansky K, Rodriguez-Galindo C.
    Journal: J Pediatr Hematol Oncol; 2004 Feb; 26(2):142-5. PubMed ID: 14767209.
    Abstract:
    Patients with essential thrombocythemia (ET) usually have normal thrombopoietin (TPO) concentrations because of negative feedback from thrombocytosis. TPO mutations in familial ET cases result in increased translation efficiency with excessive TPO stimulation and thrombocytosis. The authors describe an infant with a high platelet count (1300 x 103/mm3) and an elevated TPO concentration who was successfully treated with anagrelide. Sequencing of TPO revealed no genetic cause. This case may represent a case of atypical ET in which thrombocytosis results from TPO stimulation rather than clonal proliferation. Measuring TPO concentrations may be warranted for children with unexplained extreme thrombocytosis.
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