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  • Title: [Effect of ligustrazine on cell cycle and prostacyclin of injured vascular endothelial cells induced by hypoxia and lack of glucose].
    Author: Lin R, Liu J, Gan W.
    Journal: Zhong Yao Cai; 2003 Oct; 26(10):728-30. PubMed ID: 14768390.
    Abstract:
    OBJECTIVE: To study the effects of ligustrazine on cell cycle and prostacyclin of injured human umbilical vein vascular endothelial cell line induced by hypoxia and lack of glucose. METHODS: The experiments were performed by culturing vascular endothelial cell induced by hypoxia and lack of glucose in vitro. Cell viability was assessed by MTT assay and cell cycle was observed by flow cytometry. Radioimmunoassay (RIA) was used to assess the amount of prostacyclin (PGI2). RESULTS: The vascular endothelial cell viability and PGI2 were decreased in condition of hypoxia and lack of glucose-injury. Preincubation of vascular endothelial cell with Ligustrazine for 24 h significantly increased the cell viability, S-Phase cell, G2M-phase cell and PGI2 level. CONCLUSION: These results demonstrated that ligustrazine had protective effect on hypoxia and lack of glucose-injured vascular endothelial cell and the effect may be related to increasing cell viability, S-phase cell, G2M-phase cell and level of PGI2.
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