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  • Title: Tannin inhibits HIV-1 entry by targeting gp41.
    Author: Lü L, Liu SW, Jiang SB, Wu SG.
    Journal: Acta Pharmacol Sin; 2004 Feb; 25(2):213-8. PubMed ID: 14769212.
    Abstract:
    AIM: To investigate the mechanism by which tannin inhibits HIV-1 entry into target cells. METHODS: The inhibitory activity of tannin on HIV-1 replication and entry was detected by p24 production and HIV-1-mediated cell fusion, respectively. The inhibitory activity on the gp41 six-helix bundle formation was determined by an improved sandwich ELISA. RESULTS: Tannins from different sources showed potent inhibitory activity on HIV-1 replication, HIV-1-mediated cell fusion, and the gp41 six-helix bundle formation. CONCLUSION: Tannin inhibits HIV-1 entry into target cells by interfering with the gp41 six-helix bundle formation, thus blocking HIV-1 fusion with the target cell.
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