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  • Title: Longitudinal myelitis as an initial manifestation of systemic lupus erythematosus.
    Author: Chen HC, Lai JH, Juan CJ, Kuo SY, Chen CH, Chang DM.
    Journal: Am J Med Sci; 2004 Feb; 327(2):105-8. PubMed ID: 14770030.
    Abstract:
    Transverse myelitis is a rare and serious complication of systemic lupus erythematosus (SLE). A longitudinal involvement of the spinal cord with lupus-related transverse myelitis is more unusual. Only 7 cases have been reported. We describe a 53-year-old woman presenting with short-term paraplegia as an initial manifestation of SLE with longitudinal myelitis. She had a partial response to treatment with pulse cyclophosphamide and high-dose corticosteroids after follow-up more than 2 years. To the best of our knowledge, this is the first case report of "longitudinal" myelitis as an initial presentation of SLE. Magnetic resonance imaging typically shows increased signal intensity in T2-weighted images, cord swelling, and contrast enhancement over several spinal segments. The possibility of SLE should be kept in mind in women presenting with paraplegia with no apparent cause.
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