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  • Title: Lithium in combination with perphenazine: effect on plasma monoamine metabolites.
    Author: Bowers MB, Mazure CM, Nelson JC, Jatlow PI.
    Journal: Biol Psychiatry; 1992 Dec 15; 32(12):1102-7. PubMed ID: 1477190.
    Abstract:
    The addition of lithium to perphenazine altered the pattern of plasma homovanillic acid (HVA) during the course of treatment for acute psychosis. In the perphenazine-treated group plasma HVA declined significantly by days 7-9 of treatment, whereas in the perphenazine-plus-lithium group plasma HVA tended to increase. The pattern for plasma methoxyhydroxyphenethyl-glycol (MHPG) was not significantly different for the two groups. The addition of lithium to a neuroleptic may enhance the metabolism of dopamine.
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