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  • Title: Effect of extracellular calcium concentration on angiotensin AT1 receptor-mediated smooth muscle contraction and antagonism in rabbit aorta.
    Author: Liu YJ.
    Journal: Eur J Pharmacol; 1992 Nov 17; 223(2-3):205-9. PubMed ID: 1478269.
    Abstract:
    Angiotensin-II (AII) stimulates smooth muscle contraction by activating angiotensin AT1 receptor which induces intracellular Ca2+ release and Ca2+ influx from extracellular space. In this study, effect of extracellular Ca2+ concentration ([Ca2+]0) on angiotensin AT1 receptor-mediated contractile response to AII has been examined in the absence and presence of [Sar1,Ala8]AII in rabbit aorta. A decrease in agonist potency and an increase in antagonist potency for depression were observed in low [Ca2+]0. Data were interpreted by applying an explanatory model developed previously. The result indicates that [Ca2+]0 is linked to the efficacy expression of AII at angiotensin AT1 receptor and this prompted speculation about the underlying mechanism.
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