These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Bioprocess factors affecting glycoprotein oligosaccharide structure.
    Author: Goochee CF.
    Journal: Dev Biol Stand; 1992; 76():95-104. PubMed ID: 1478360.
    Abstract:
    The oligosaccharide structures of glycoproteins can have a profound effect on properties critical to the development of glycoprotein products for human therapeutic or diagnostic use, including clearance rate, antigenicity, specific activity, solubility, resistance to thermal inactivation, and resistance to protease attack. Therefore, it is important to understand how bioprocess factors influence oligosaccharide structure. In this presentation, I will summarize literature data concerning potential effects of bioprocess factors on glycoprotein oligosaccharide biosynthesis. These data are drawn from two recent detailed reviews published by our laboratory describing the effect of cell culture conditions on N-linked glycosylation (10) and the effects of other bioprocess factors on both N-linked and O-linked glycosylation (11).
    [Abstract] [Full Text] [Related] [New Search]