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  • Title: Evolutionary stability of transspecies major histocompatibility complex class II DRB lineages in humans and rhesus monkeys.
    Author: Slierendregt BL, van Noort JT, Bakas RM, Otting N, Jonker M, Bontrop RE.
    Journal: Hum Immunol; 1992 Sep; 35(1):29-39. PubMed ID: 1478892.
    Abstract:
    Sequence analysis of rhesus monkey (Macaca mulatta) polymorphic second exon of major histocompatibility complex class II DRB subregion genes demonstrates the existence of at least 34 alleles. Some of these rhesus monkey alleles are very similar (or nearly identical) to HLA-DRB alleles. These data demonstrate that members of the lineages for Mhc-DRB1*03, -DRB1*04, -DRB1*10, and the loci of Mhc-DRB3, -DRB4, -DRB5, and -DRB6 predate speciation of man and rhesus monkey and were already present 25 million years ago. Calculation of evolutionary rates suggests that the various allele lineages have differential stabilities. Furthermore, the data indicate that distinct species may not have inherited or lost transspecies Mhc-DRB lineages in evolution, because several allele lineages in rhesus monkeys appear to be absent in humans and vice versa.
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