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  • Title: Synthesis, structure and biological activity of 1,2,4-triazolo-1,3-thiazine derivatives.
    Author: Foks H, Rudnicka W, Głowka M, Kaliszan R, Nasal A, Damasiewicz B, Radwańska A, Petrusewicz J, Trzeciak H, Okopień B.
    Journal: Pharmazie; 1992 Oct; 47(10):770-3. PubMed ID: 1480655.
    Abstract:
    A group of condensed triazole-thiazine derivatives (2a-i, 3b, 3j) was obtained in reaction of the corresponding 5-substituted 1,2,4-triazole-3-thiones (1a-j) with epichlorohydrin in alkaline medium. The structure of the compounds synthesized was confirmed by spectral and roentgenographic methods. Tuberculostatic and circulatory activities of the compounds were also studied.
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