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  • Title: Vertical transmission of HTLV-1 in HTLV-1 carrier rat.
    Author: Ami Y, Kushida S, Matsumura M, Yoshida Y, Kameyama T, Sugiyama Y, Yagami K, Uchida M, Uchida K, Koiso K.
    Journal: Jpn J Cancer Res; 1992 Dec; 83(12):1241-3. PubMed ID: 1483938.
    Abstract:
    A female F344 rat was injected with 2.4 x 10(6) MT-2 cells intravenously at 3 and 4 weeks old, and was mated with a non-infected male rat at the 17th week after injection, when the dam rat contained HTLV-1 provirus in the peripheral blood mononuclear cells as determined by polymerase chain reaction. HTLV-1 provirus was detected in at least 2 out of 9 offspring. This system should be useful for studies on the routes and prevention of vertical transmission and on elimination of once-transmitted HTLV-1.
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