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  • Title: Dendrotoxin-like effects of noxiustoxin.
    Author: Harvey AL, Marshall DL, Possani LD.
    Journal: Toxicon; 1992 Nov; 30(11):1497-500. PubMed ID: 1485346.
    Abstract:
    Noxiustoxin from the Mexican scorpion (Centruroides noxius Hoffmann) is known to block neuronal K+ channels. Noxiustoxin facilitated acetylcholine release in chick biventer cervicis nerve-muscle preparations, but not in mouse phrenic nerve-hemidiaphragm preparations. Noxiustoxin displaced binding of a radiolabelled dendrotoxin from synaptosomal membranes from rat brain, with a Ki of 10(-10) M. It is concluded that noxiustoxin shares some pharmacological properties with the K+ channel blocking dendrotoxins.
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