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  • Title: Formation of a stable 99mTc-tri-hydrazidophosphine oxide (99mTc-THP) chelate.
    Author: Corlija M, Katti KV, Volkert WA, Hoffman TJ, Higginbotham C, Holmes RA.
    Journal: J Nucl Biol Med (1991); 1992; 36(3):296-300. PubMed ID: 1486126.
    Abstract:
    Atri-hydrazidophosphine oxide (THP) ligand was synthesized and used to complex 99mTc in high yield (> 95%) by Sn(II) reduction of 99mTcO4-. 99mTc-THP has excellent stability in both 0.9% acqueous NaCl at neutral pH and in human serum at 37 degrees C. Biodistribution studies indicate minimal organ specificity and no significant in vivo release of 99mTcO4-. The ease of 99mTc complexation with THP and the high stability of 99mTc-THP suggests that this ligand may be used as a basis for the development of new imaging agents.
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