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  • Title: Fertility in myotonic dystrophy in Saguenay-Lac-St-Jean: a historical perspective.
    Author: Dao TN, Mathieu J, Bouchard JP, De Braekeleer M.
    Journal: Clin Genet; 1992 Nov; 42(5):234-9. PubMed ID: 1486700.
    Abstract:
    Myotonic dystrophy (MD) is an autosomal dominant disorder that has a high prevalence in Saguenay-Lac-St-Jean. A case-control study, based on a population register, of 373 MD patients who married in this region between 1855 and 1971 was conducted to determine whether their fertility was affected by the disorder. Six demographic parameters, that is the number of children, the age at marriage, the ages at the time of birth of the first and the last child, the interval between the marriage and the birth of the first child, and the interval between consecutive births, were analyzed. The mean number of children born to MD and control individuals was not different (P > 0.05). However, MD males had more children than MD females although they have started delaying their marriage since 1921. Fertility fell significantly in both the MD and control groups during the period of observation. This change reflects the decline in fertility of French Canadians in general during this period, but mainly after 1940.
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