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  • Title: Comparative activity of the topical quinolone OPC-7251 against bacteria associated with acne vulgaris.
    Author: Vogt K, Hermann J, Blume U, Gollnick H, Hahn H, Haustein UF, Orfanos CE.
    Journal: Eur J Clin Microbiol Infect Dis; 1992 Oct; 11(10):943-5. PubMed ID: 1486893.
    Abstract:
    The antibacterial activity of the topical quinolone OPC-7251 against bacteria commonly found in acne vulgaris was tested in vitro by an agar dilution method. The MIC50 was 0.25 mg/l for Propionibacterium acnes, 0.125 mg/l for Propionibacterium granulosum, 0.03 mg/l for Staphylococcus aureus and 0.06 mg/l for coagulase-negative staphylococci. Compared with seven other antibiotics tested (ciprofloxacin, penicillin, erythromycin, tetracycline, clindamycin, fusidic acid and gentamicin), OPC-7251 had potent activity against both propionibacteria and staphylococci and the lowest incidence of resistant strains.
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