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  • Title: Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use.
    Author: Depré M, van Hecken A, Verbesselt R, Tjandra-Maga TB, Gerin M, de Schepper PJ.
    Journal: Fundam Clin Pharmacol; 1992; 6(6):259-62. PubMed ID: 1487229.
    Abstract:
    In 12 healthy volunteers, paracetamol pharmacokinetics were compared following administration of 1 g propacetamol HCl given intravenously over a 15-min period and 500 mg paracetamol given orally. Mean +/- SD total AUC (microgram/ml.h) following the iv formulation was significantly (P < 0.01) greater than following oral paracetamol (25.53 +/- 4.27 vs 21.04 +/- 4.49) corresponding to a mean oral bioavailability of paracetamol of 82.2 +/- 9.4%. Between 1 and 2 h after administration, paracetamol plasma concentrations became very similar following both formulations. In another study, 2 g propacetamol HCl was given both as a 15-min infusion and as a 2-min bolus injection to six healthy volunteers. Contrary to mild to moderate local discomfort experienced during the 2-min bolus injection, the 15-min infusion was well tolerated without any complaints reported.
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