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  • Title: Pharmacokinetics of HEPP, a new anticonvulsant, in healthy subjects and rabbits after multiple doses.
    Author: González-Esquivel DF, Pérez RM, Cook HJ.
    Journal: Biopharm Drug Dispos; 2004 Mar; 25(2):85-90. PubMed ID: 14872556.
    Abstract:
    In the present study the pharmacokinetics of D,L-3hydroxy-3-phenylpropionamide (HEPP) a new anticonvulsant compound was studied after multiple dose administration in healthy male volunteers and in rabbits. The study in humans involved the oral administration of 375 mg of HEPP b.i.d. for 7 consecutive days. The study in rabbits explored doses of 30 mg/kg intraperitoneal (i.p.) given once daily for 6 days. In both studies pharmacokinetic (PK) profiles were characterized after the first dose and after the last multiple dose. Plasma HEPP concentrations were measured by HPLC. Pharmacokinetic parameters were calculated by noncompartmental methods. The results in humans as well as in rabbits showed that after multiple doses the AUC values decreased and CL/F values were significantly increased, which could be due to an induction process in the metabolic disposition of the drug.
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