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  • Title: Paroxetine in the treatment of melancholia and severe depression.
    Author: Tignol J, Stoker MJ, Dunbar GC.
    Journal: Int Clin Psychopharmacol; 1992 Nov; 7(2):91-4. PubMed ID: 1487627.
    Abstract:
    Meta-analyses of the worldwide paroxetine database assessed the efficacy of this compound in the treatment of both DSM-III defined melancholia and hospitalised patients with severe depression (HAMD > or = 25). The analysis for melancholia included 178 paroxetine treated patients and 66 patients treated with placebo. Paroxetine was significantly superior to placebo in the treatment of melancholia and a clear dose-response relationship was established. The meta-analysis for severely depressed hospitalised patients included 109 paroxetine treated patients and 107 patients treated with a tricyclic/tetracyclic control. Paroxetine and active controls showed comparable efficacy in the treatment of severely depressed hospitalised patients.
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