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  • Title: Regeneration of respiratory epithelia in the rat after free grafting.
    Author: Bootz F, Reuter G.
    Journal: Eur Arch Otorhinolaryngol; 1992; 249(7):359-63. PubMed ID: 1489532.
    Abstract:
    Following free grafting of septal mucosa from the rat to the rectus abdominis muscle, the mucosal membrane was found to degenerate into a flat squamous epithelium with loss of the majority of differentiated epithelial cells. Both the goblet cells and ciliated cells regenerated from stem cells, which appear in large numbers 2 days after transplantation. Microvilli were found initially on the surfaces of developing ciliated cells and were replaced 21 days post-grafting by cilia. The number of goblet cells during regeneration at first exceeded that of the ciliated cells, but decreased with the passage of time. After 4 months there were more ciliated cells, with the respiratory epithelium now appearing no different than the initially transplanted nasal mucosa.
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